In US clinical trials, a psychedelic treatment can cost about US$15,000 per patient due to Schedule I research burdens, versus $50 for mushroom chocolates on the street.

“what you could get on the street very easily, mushroom chocolates or otherwise for $50 for a patient in a proper clinical trial run at a university will cost could cost $15,000 per person, right?”

Gurley distinguishes speaking for science from speaking for scientific inquiry, arguing that no authority should be able to tell someone they cannot search and that searching for truth does not make a person bad.

“I can't tell you that I speak for science like Anthony Fouchy did, but I can tell you I speak for scientific inquiry. There's no one that should be telling you you can't search. That makes no sense whatsoever. You're not a bad person if you search. You're a good person if you search.”

The Treasury buyback size is trivial versus daily volume, but the market is trading the signal that the Treasury Secretary is concerned about long-end demand.

“increasing the buybacks by $2 billion is is a drop in the bucket compared to the daily trade volume as well as the the total notional outstanding. But it's the signal that it's sending and that's what the market's focused on is the signal that it's sending, not necessarily the the the benefit”

Pass-through wealth is not dominated by large monopoly-style businesses passively collecting income, but by millions of mid-market regional businesses actively operated by their owners.

“We didn't really know if this is like Monopoly Man, big business, that you're just passively collecting the income, or what we turned out to find, it was sort of these mid-market regional businesses of which there were just millions of them across the country.”

Retaliating against intelligence officers for past truthful analysis that an administration didn't want to hear is a new institutional feature enshrined by the current administration.

“never was there a situation where retaliating against the messenger for telling hard truths that the administration didn't want to hear, that is the new feature that this administration has enshrined.”

AI companies will not unilaterally stop racing due to IPOs, competition, and animosity between principals.

“I'm not going to stop racing because you know >> there's IPOs at stake. There is a competition at stake. There's also some animosity between the people. So like I'm not going to stop unilaterally. I'll be a sucker.”

'Normal' is not an acceptable test for a CIA director; Ratcliffe's apparent normalcy masks failure by every meaningful standard.

“there's a word going around town that Mr. Ratcliffe is the adult in the room. You know, I mean, he has no obvious grift. He's got no guru that we can locate. You know, he reads like an adult, but normal is not an acceptable test for a CIA director.”