What is Novo Nordisk?

Novo Nordisk's ziltavecumab cardiovascular studies were halted by an IDMC for futility, adding another failure to the record of IL-6 inhibition in cardiovascular disease.

“They halted the two additional trials there. So another different sort of novel use of iL-6 in inflammation in, in cardiovascular failed as well.”

Companies structured as perpetual purpose trusts, such as Novo Nordisk and Zeiss, are six times more likely to survive to year 50 than conventionally structured counterparts.

“Companies with that structure like Novo and Zeiss, they are six times more likely to live to year 50 compared to their conventional counterparts.”

Perpetual purpose trusts (and related 'spiritual holding company' structures including employee ownership trusts and non-profit foundations) are worth watching as a governance category that demonstrably outperforms conventional corporate structures on longevity, R&D investment, and shareholder returns.

“I use the omnibus term spiritual holding company to describe this category of things.”

Major pharma companies including Sanofi and Novo Nordisk are voluntarily capping price increases at or below medical inflation, suggesting industry self-regulation may be emerging ahead of government mandates.

“Sanapy earlier this year said that they were they will not increase drug prices beyond the rate of medical inflation.”