What is cortisol?
cortisol
Cortisol is a steroid hormone produced by the adrenal cortex that regulates stress responses and metabolism. Research and clinical observations have explored its role in stress, metabolism, and immune function, with findings indicating that acute cortisol spikes can enhance immune responses, while chronic stress patterns may amplify cortisol reactivity.
How it developed
- Jul 2026 - Andrew Huberman said that if morning cortisol is high and can be made higher through certain activities, it ensures evening and nighttime cortisol is low, which sets up an increase in melatonin.
- Jul 2026 - Martin Picard said that the stress hormone increased energy expenditure, or the cost of life, by 60%.
- Sep 2026 - Carmine Pariante said that alcohol actually increases cortisol and does not reduce stress, but merely numbs the person to it.
- Sep 2026 - Carmine Pariante said that in a study of singing groups for postnatal depression, a one-hour singing session led to a reduction in cortisol and inflammation.
- Sep 2026 - Carmine Pariante said that when facing a small stress in the context of ongoing stress, cortisol goes up more and higher.
- Aug 2026 - Max Krummel said that the immune-enhancing effects of acute cortisol and stress are important and have been overlooked.
In the evidence
Every line below is attributed to a named speaker.
High morning cortisol, driven by bright light, caffeine, or exercise, suppresses evening and nighttime cortisol and thereby enables robust melatonin production for sleep.
“If your morning cortisol is high and you can make it higher doing any number of the things I just It ensures that your evening and nighttime cortisol is low and that's what sets you up for an increase in melatonin.”Andrew Huberman · 22 Jul 2026
The stress hormone cortisol increases cellular energy expenditure by 60 percent, according to Martin Picard's research.
“We found that the stress hormone increased energy expenditure like the cost of life by 60%.”Martin Picard · 2 Jul 2026
Alcohol increases cortisol and numbs rather than relieves stress, according to psychiatrist Carmine Pariante.
“This thing about alcohol that it actually increases my cortisol and so it doesn't actually reduce my stress. It just sort of numbs me to it.”Carmine Pariante · 3 Sep 2026
A single one-hour group singing session measurably reduced both cortisol and inflammation markers in women with postnatal depression, measured before and after the session.
“We recently did some work using singing groups from other that were suffering from postnatal depression. And we measured literally from before the singing session, one hour singing session to the end of the singing session, a reduction in cortisol and in inflammation.”Carmine Pariante · 3 Sep 2026
Alcohol does not reduce stress but raises cortisol, and feeling it dramatically lowers your stress is a signal you are drinking too much.
“If you feel that it's actually reducing your stress a lot while you're drinking, you're probably drinking too much.”Carmine Pariante · 3 Sep 2026
Chronic stress amplifies acute stress responses: a small additional stressor on top of ongoing chronic stress produces a cortisol spike that is both faster and higher than it would be in a non-stressed baseline.
“When you're facing a small stress in the context of the ongoing stress then your cortisol goes up more and goes up higher.”Carmine Pariante · 3 Sep 2026
Acute cortisol and short-term stress are immune-enhancing, a benefit that has been overlooked because research focuses on chronic cortisol's suppressive effects.
“The immune-enhancing effects of acute cortisol and stress are really important and I think they've been overlooked.”Max Krummel · 3 Aug 2026
The popular internet 'cortisol cocktail' (orange juice, coconut water, salt, magnesium) has no identifiable physiological mechanism that would specifically affect cortisol, according to a leading psychiatrist.
“To me, it doesn't ring any bell cuz I cannot link any of this compound or things in the cocktail to anything that particular would affect.”Carmine Pariante · 3 Sep 2026